The syndrome of inappropriate antidiuresis.

نویسنده

  • David C Lowance
چکیده

From the Division of Nephrology and Hypertension and the Department of Physiology and Pharmacology, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, OR (D.H.E.); and the Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver (T.B.). Address reprint requests to Dr. Ellison at the Division of Nephrology and Hypertension, Oregon Health and Science University, PP262, 3314 SW U.S. Veterans Hospital Rd., Portland, OR 97239, or at ellisond@ ohsu.edu.

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Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a recently described genetic cause of hyponatremia in male infants. Whether this X-linked condition could be detected in the adult or also could affect women is unknown. A large five-generation family was identified in which the recently described arginine-vasopressin receptor type 2 (AVPR2) mutation that is responsible for NSIAD was...

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Case Report Long-TermOutcomes in a Family with Nephrogenic Syndrome of Inappropriate Antidiuresis

We report a familial case of the nephrogenic syndrome of inappropriate antidiuresis (NSIAD), including 30-year followup data on two patients. The proband and one maternal uncle presented in their infancy with severe recurrent hyponatremia, and clinical pictures consistent with the syndrome of inappropriate antidiuretic hormone (SIADH) in the absence of an elevated ADH level. They were both conf...

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عنوان ژورنال:
  • The New England journal of medicine

دوره 357 9  شماره 

صفحات  -

تاریخ انتشار 2007